Guadecitabine sodium
Data Sheet
For research use only. Not for human use.
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| CAS No. | 929904-85-8 | Cat. No. | BCP24636 |
| Name | Guadecitabine sodium | ||
| Synonyms | SGI110; SGI-110; SGI 110; S110;SGI-110 sodium；S-110 sodium; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H23N9NaO10P | M. Wt | 579.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. | ||
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