Golotimod
| CAS号 | 229305-39-9 | 货号 | BCP24651 |
| 中文名 | Golotimod | ||
| 英文名 | Golotimod | ||
| 中文别名 | gamma-D-谷氨酰-L-色氨酸; | ||
| 英文别名 | H-D-Glu(L-Trp-OH)-OH;SCV 07;gamma-D-Glu-L-trp;SCV-07;SCV07; | ||
| 分子式 | C16H19N3O5 | 分子量 | 333.34 |
| 生物活性 | Golotimod is an orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes, in particular the helper T (Th1) cells, activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression. | ||
| 信号通路 | Jak/Stat Pathway Others Pathway Wnt/Stem Cell | ||
| 靶 点 | Stat TLR | ||
结构式
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