Vactosertib
| CAS No. | 1352608-82-2 | Cat. No. | BCP18384 |
| Name | Vactosertib | ||
| Synonyms | TEW7197; TEW 7197; TEW-7197EW 7197;EW7197;EW-7197; | ||
| Formula | C22H18FN7 | M. Wt | 399.42 |
| Description | Vactosertib, also known as EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. | ||
| Pathways | TGF beta/Smad | ||
| Targets | BMP/TGF beta Receptor | ||
Structure
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