因多昔芬盐酸盐
| CAS号 | 1197194-41-4 | 货号 | BCP24689 |
| 中文名 | 因多昔芬盐酸盐 | ||
| 英文名 | Endoxifen hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Endoxifen HCl;Z-Endoxifen hydrochloride; | ||
| 分子式 | C25H28ClNO2 | 分子量 | 409.95 |
| 生物活性 | Endoxifen Hydrochloride is the hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA and thus reducing DNA synthesis. Unlike tamoxifen, however, which relies on CYP2D6 activity for its conversion to the active metabolite endoxifen, the direct administration of endoxifen bypasses the CYP2D6 route. As CYP2D6 activity can vary widely among individuals due to genetic CYP2D6 polymorphisms, endoxifen is therefore theoretically more potent and more uniform in its bioavailability across patient populations. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Estrogen Receptor | ||
结构式
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