因多昔芬盐酸盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24689CAS号：1197194-41-4纯度：98%

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CAS号	1197194-41-4	货号	BCP24689
中文名	因多昔芬盐酸盐
英文名	Endoxifen hydrochloride
中文别名
英文别名	Endoxifen HCl;Z-Endoxifen hydrochloride;
SMILES	CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3.Cl
化学名称
分子式	C25H28ClNO2	分子量	409.95
纯度	98%	配送	惯例下常温包邮
产品描述	Endoxifen Hydrochloride is the hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA and thus reducing DNA synthesis. Unlike tamoxifen, however, which relies on CYP2D6 activity for its conversion to the active metabolite endoxifen, the direct administration of endoxifen bypasses the CYP2D6 route. As CYP2D6 activity can vary widely among individuals due to genetic CYP2D6 polymorphisms, endoxifen is therefore theoretically more potent and more uniform in its bioavailability across patient populations.

因多昔芬盐酸盐 新