RSL3
| CAS No. | 1219810-16-8 | Cat. No. | BCP18763 |
| Name | RSL3 | ||
| Synonyms | RSL3 1S,3R-;1S,3R-RSL3;RSL-3; | ||
| Formula | C23H21ClN2O5 | M. Wt | 440.88 |
| Description | (1S,3R)-RSL3 is a direct inhibitor of glutathione peroxidase 4 (GPx4). By inhibiting GPx4 activity, (1S,3R)-RSL3 triggers a lethal accumulation of lipid hydroperoxides and induces ferroptotic cell death (EC50 = 0.01 μM in HRASV12-expressing cells). | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Ferroptosis | ||
Structure
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