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CAS No. | 1219810-16-8 | Cat. No. | BCP18763 |
Name | RSL3 | ||
Synonyms | RSL3 1S,3R-;1S,3R-RSL3;RSL-3; | ||
SMILES | COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24 | ||
Chemical Name | |||
Formula | C23H21ClN2O5 | M. Wt | 440.88 |
Purity | 98% | Storage | Store at 4-8°C |
Description | (1S,3R)-RSL3 is a direct inhibitor of glutathione peroxidase 4 (GPx4). By inhibiting GPx4 activity, (1S,3R)-RSL3 triggers a lethal accumulation of lipid hydroperoxides and induces ferroptotic cell death (EC50 = 0.01 μM in HRASV12-expressing cells). |
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