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RSL3 Chemical Structure

RSL3

Data Sheet For research use only. Not for human use.
Cat. No. :BCP18763CAS No. :1219810-16-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1219810-16-8 Cat. No. BCP18763
Name RSL3
Synonyms RSL3 1S,3R-;1S,3R-RSL3;RSL-3;
SMILES COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
Chemical Name
Formula C23H21ClN2O5 M. Wt 440.88
Purity 98% Storage Store at 4-8°C
Description (1S,3R)-RSL3 is a direct inhibitor of glutathione peroxidase 4 (GPx4). By inhibiting GPx4 activity, (1S,3R)-RSL3 triggers a lethal accumulation of lipid hydroperoxides and induces ferroptotic cell death (EC50 = 0.01 μM in HRASV12-expressing cells).
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