Upadacitinib tartrate

  • Chemical Properties
CAS No. 1607431-21-9 Cat. No. BCP19012
Name Upadacitinib tartrate
Synonyms ABT-494 tartrate;ABT494 tartrate;ABT 494 tartrate;
Formula C21H25F3N6O7 M. Wt 530.46
  • Biological Activity
Description Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.
Related Products 2050057-56-0(Upadacitinib hemihydrate) 1310726-60-3(Upadacitinib)
Pathways Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics 
Targets JAK 

Structure

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