Remodelin hydrobromide
| CAS号 | 1622921-15-6 | 货号 | BCP19055 |
| 中文名 | Remodelin hydrobromide | ||
| 英文名 | Remodelin hydrobromide | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C15H15BrN4S | 分子量 | 363.28 |
| 生物活性 | Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Acetyltransferase | ||
结构式
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