Remodelin hydrobromide

参考资料仅供科学研究，不可用于个人用途。

货号：BCP19055CAS号：1622921-15-6纯度：98%

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CAS号	1622921-15-6	货号	BCP19055
中文名	Remodelin hydrobromide
英文名	Remodelin hydrobromide
中文别名
英文别名
SMILES
化学名称
分子式	C15H15BrN4S	分子量	363.28
纯度	98%	配送	惯例下常温包邮
产品描述	Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.