Blarcamesine hydrochloride
| CAS号 | 195615-84-0 | 货号 | BCP24794 |
| 中文名 | Blarcamesine hydrochloride | ||
| 英文名 | Blarcamesine hydrochloride | ||
| 中文别名 | |||
| 英文别名 | AVex-73 hydrochloride;Anavex-2-73 HCl;Anavex 2-73; Anavex2-73; Anavex 2-73; Anavex-273; Anavex273; Anavex 273; AE-37 hydrochloride; | ||
| 分子式 | C19H24ClNO | 分子量 | 317.85 |
| 生物活性 | Anavex2-73 is a muscarinic/σ1 ligand. ANAVEX2-73 (0.01-3.0 mg/kg i.p.) alleviated the scopolamine- and dizocilpine-induced learning impairments. ANAVEX2-73 (300 µg/kg) also reversed the learning deficits in mice injected with Aβ(25-35) peptide, a non-transgenic Alzheimer's disease model. The neuroprotective activity of ANAVEX2-73, its mixed cholinergic/σ(1) activity, its low active dose range and its long duration of action together reinforce its therapeutic potential in Alzheimer's disease. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Sigma Receptor | ||
结构式
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