Dofequidar fumarate

  • Chemical Properties
CAS No. 153653-30-6 Cat. No. BCP24840
Name Dofequidar fumarate
Synonyms MS-209; MS 209; MS209;
Formula C34H35N3O7 M. Wt 597.66
  • Biological Activity
Description Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. Dofequidar was found to sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.
Pathways Ion Channel/Membrane Transporter 
Targets P glycoprotein 

Structure

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
Service & Tech Support:orders@biochempartner.com
Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.