Dofequidar fumarate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 153653-30-6 | Cat. No. | BCP24840 |
| Name | Dofequidar fumarate | ||
| Synonyms | MS-209; MS 209; MS209; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C34H35N3O7 | M. Wt | 597.66 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. Dofequidar was found to sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. | ||
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