BGP-15 dihydrochloride
| CAS号 | 66611-37-8 | 货号 | BCP24844 |
| 中文名 | BGP-15 dihydrochloride | ||
| 英文名 | BGP-15 dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | BGP15; BGP-15; BGP 15;BGP-15 2HCl; | ||
| 分子式 | C14H24Cl2N4O2 | 分子量 | 351.27 |
| 生物活性 | BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. BGP-15 also inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury. Moreover, BGP-15 was found to prevent imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | PARP | ||
结构式
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