BBT594
| CAS No. | 882405-89-2 | Cat. No. | BCP24855 |
| Name | BBT594 | ||
| Synonyms | BBT-594; BBT 594; NVP-BBT594; NVP BBT594; NVP BBT-594; | ||
| Formula | C28H30F3N7O3 | M. Wt | 569.58 |
| Description | BBT594, also known as NVP-BBT594, is potent and selective RET and JAK2 inhibitor. NVP-BBT594 impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. GDNF-RET signaling as a rational therapeutic target may be useful to combat or delay the onset of AI resistance in breast cancer. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | RET | ||
Structure
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