BBT594 New
Data Sheet
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| CAS No. | 882405-89-2 | Cat. No. | BCP24855 |
| Name | BBT594 | ||
| Synonyms | BBT-594; BBT 594; NVP-BBT594; NVP BBT594; NVP BBT-594; | ||
| SMILES | CC(=O)NC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(CC3)C(=O)NC4=CC(=C(C=C4)CN5CCN(CC5)C)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C28H30F3N7O3 | M. Wt | 569.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BBT594, also known as NVP-BBT594, is potent and selective RET and JAK2 inhibitor. NVP-BBT594 impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. GDNF-RET signaling as a rational therapeutic target may be useful to combat or delay the onset of AI resistance in breast cancer. | ||
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