ASK1IN1
| CAS号 | 1262041-49-5 | 货号 | BCP19368 |
| 中文名 | ASK1IN1 | ||
| 英文名 | ASK1IN1 | ||
| 中文别名 | |||
| 英文别名 | ASK1-IN-1; | ||
| 分子式 | C23H21N7O | 分子量 | 411.46 |
| 生物活性 | InVivo: ASK1-IN-1dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively). | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MAP3K | ||
结构式
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