ASK1IN1

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货号：BCP19368CAS号：1262041-49-5纯度：98%

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CAS号	1262041-49-5	货号	BCP19368
中文名	ASK1IN1
英文名	ASK1IN1
中文别名
英文别名	ASK1-IN-1;
SMILES
化学名称
分子式	C23H21N7O	分子量	411.46
纯度	98%	配送	惯例下常温包邮
产品描述	InVivo: ASK1-IN-1dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively).