Halofuginone hydrobromide
CAS No. | 17395-31-2 | Cat. No. | BCP24882 |
Name | Halofuginone hydrobromide | ||
Synonyms | RU-19110 hydrobromide; | ||
Formula | C16H18Br2ClN3O3 | M. Wt | 495.59 |
Description | Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. | ||
Pathways | TGF beta/Smad | ||
Targets | TGF β/Smad |
Structure
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