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Halofuginone hydrobromide Chemical Structure

Halofuginone hydrobromide

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24882CAS No. :17395-31-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 17395-31-2 Cat. No. BCP24882
Name Halofuginone hydrobromide
Synonyms RU-19110 hydrobromide;
SMILES C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
Chemical Name
Formula C16H18Br2ClN3O3 M. Wt 495.59
Purity 98% Storage Store at 4-8°C
Description Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
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