ON1231320
| CAS No. | 131247-39-8 | Cat. No. | BCP19609 |
| Name | ON1231320 | ||
| Synonyms | ON-1231320;ON 1231320;GBO-006; GBO006; GBO 006; | ||
| Formula | C22H15F2N5O3S | M. Wt | 467.45 |
| Description | ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. The cytotoxic effect of the drug is mediated by apoptosis as evidenced by the induction of Caspase 3/7 activity and by the cleavage of PARP in a dose dependent manner. ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PLK | ||
Structure
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