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ON1231320 Chemical Structure

ON1231320

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19609CAS No. ：131247-39-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 131247-39-8 Cat. No. BCP19609
Name ON1231320
Synonyms ON-1231320;ON 1231320;GBO-006; GBO006; GBO 006;
SMILES
Chemical Name
Formula C22H15F2N5O3S M. Wt 467.45
Purity 98% Storage Store at 4-8°C
Description ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. The cytotoxic effect of the drug is mediated by apoptosis as evidenced by the induction of Caspase 3/7 activity and by the cleavage of PARP in a dose dependent manner. ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts.
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