BAR501
| CAS No. | 1632118-69-4 | Cat. No. | BCP24972 |
| Name | BAR501 | ||
| Synonyms | BAR-501; BAR 501; | ||
| Formula | C26H46O3 | M. Wt | 406.64 |
| Description | BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent models of portal hypertension by exerting genomic and non-genomic effects on CSE, eNOS and ET-1 in liver sinusoidal cells. | ||
| Pathways | GPCR/G Protein | ||
| Targets | TGR5 | ||
Structure
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