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BAR501 Chemical Structure

BAR501

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24972CAS No. :1632118-69-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1632118-69-4 Cat. No. BCP24972
Name BAR501
Synonyms BAR-501; BAR 501;
SMILES C[C@H](CCCO)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Chemical Name
Formula C26H46O3 M. Wt 406.64
Purity 98% Storage Store at 4-8°C
Description BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent models of portal hypertension by exerting genomic and non-genomic effects on CSE, eNOS and ET-1 in liver sinusoidal cells.
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