盐酸氟西汀
| CAS号 | 56296-78-7 | 货号 | BCP19962 |
| 中文名 | 盐酸氟西汀 | ||
| 英文名 | Fluoxetine hydrochloride | ||
| 中文别名 | |||
| 英文别名 | LY110140;LY-110140;LY 110140; | ||
| 分子式 | C17H19ClF3NO | 分子量 | 345.79 |
| 生物活性 | Fluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Fluoxetine HCl antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Fluoxetine HCl-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia [1]. Administration of fluoxetine (10 mg/kg, i.p.) alone also decreased the number of spontaneously active serotonergic neurons. However, when administered following fluoxetine, pindolol significantly attenuated, but did not block completely, the inhibitory effects of fluoxetine on the number of spontaneously active serotonergic neurons. These results indicate that pindolol can attenuate the effects of fluoxetine on the firing of serotonergic neurons. These results may help explain the varying efficacy of pindolol in clinical trials with SSRIs. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | SSRI | ||
结构式
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