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Fluoxetine hydrochloride 结构式

盐酸氟西汀

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货号 :BCP19962CAS号 :56296-78-7纯度:98%
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  • 基本信息与产品描述
CAS号 56296-78-7 货号 BCP19962
中文名 盐酸氟西汀
英文名 Fluoxetine hydrochloride
中文别名
英文别名 LY110140;LY-110140;LY 110140;
SMILES
化学名称
分子式 C17H19ClF3NO 分子量 345.79
纯度 98% 配送 惯例下常温包邮
产品描述 Fluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Fluoxetine HCl antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Fluoxetine HCl-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia [1]. Administration of fluoxetine (10 mg/kg, i.p.) alone also decreased the number of spontaneously active serotonergic neurons. However, when administered following fluoxetine, pindolol significantly attenuated, but did not block completely, the inhibitory effects of fluoxetine on the number of spontaneously active serotonergic neurons. These results indicate that pindolol can attenuate the effects of fluoxetine on the firing of serotonergic neurons. These results may help explain the varying efficacy of pindolol in clinical trials with SSRIs.
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