Edicotinib
| CAS No. | 1142363-52-7 | Cat. No. | BCP25086 |
| Name | Edicotinib | ||
| Synonyms | JNJ40346527; JNJ 40346527; JNJ-40346527; | ||
| Formula | C27H35N5O2 | M. Wt | 461.61 |
| Description | Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | cFMS | ||
Structure
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