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Edicotinib Chemical Structure

Edicotinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP25086CAS No. :1142363-52-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1142363-52-7 Cat. No. BCP25086
Name Edicotinib
Synonyms JNJ40346527; JNJ 40346527; JNJ-40346527;
SMILES
Chemical Name
Formula C27H35N5O2 M. Wt 461.61
Purity 98% Storage Store at 4-8°C
Description Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells.
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