Olumacostat glasaretil

Description	Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo.
Pathways	Protease/Metabolic Enzyme
Targets	ACC

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