Olumacostat glasaretil
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1261491-89-7 | Cat. No. | BCP25136 |
| Name | Olumacostat glasaretil | ||
| Synonyms | DRM01B; DRM-01B; DRM 01B; | ||
| SMILES | O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O | ||
| Chemical Name | |||
| Formula | C26H43NO7 | M. Wt | 481.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo. | ||
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