BMS-986205
  • 化学数据
CAS号 1923833-60-6 货号 BCP20339
中文名 BMS-986205
英文名 BMS986205
中文别名
英文别名 BMS986205;BMS 986205; ONO-7701; ONO 7701; ONO7701; F-001287; F001287; F001287; Linrodostat;
分子式 C24H24ClFN2O 分子量 410.91
  • 用途
生物活性 BMS-986205 is a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. BMS-986205 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
信号通路 Protease/Metabolic Enzyme 
靶 点 IDO 

结构式

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