Encequidar
| CAS No. | 849675-66-7 | Cat. No. | BCP25240 |
| Name | Encequidar | ||
| Synonyms | HM30181 ;HM-30181; HM 30181;HM-30181-A; HM30181A; | ||
| Formula | C38H36N6O7 | M. Wt | 688.73 |
| Description | Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials. | ||
| Related Products | 849675-87-2（Encequidar mesylate） 2097125-58-9（Encequidar mesylate monohydrate） | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | P glycoprotein | ||
Structure
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