Org-26576

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20343CAS No. ：1026791-61-6;100044-96-0Purity：98%

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CAS No.	1026791-61-6;100044-96-0	Cat. No.	BCP20343
Name	Org-26576
Synonyms	Org26576; Org 26576;
SMILES
Chemical Name
Formula	C11H12N2O2	M. Wt	204.23
Purity	98%	Storage	Store at 4-8°C
Description	In Vitro Org 26576 represents structurally a distinct chemical series derived from the first generation ampakine CX516 and displays 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 μM in rat hippocampal primary cultured neurons. Org 26576 demonstrates selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels and kinases. In Vivo Org 26576 (1 mg/kg) produces significant increases in the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus and CA3 subfield of the hippocampus in mice[1]. Chronic administration of Org 26576 increases progenitor cell proliferation in dentate gyrus (approximately 40%) and in prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org 26576 in dentate gyrus exhibits increased rates of survival (approximately 30%) with the majority of surviving c