Apoptozole
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1054543-47-3 | Cat. No. | BCP18667 |
| Name | Apoptozole | ||
| Synonyms | Apoptosis Activator VII; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C33H25F6N3O3 | M. Wt | 625.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM).It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells. Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight. | ||
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