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SU5614 Chemical Structure

SU5614

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP16040CAS No. ：1055412-47-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1055412-47-9 Cat. No. BCP16040
Name SU5614
Synonyms SU-5614;SU 5614;
SMILES O=C1NC2=C(C=C(Cl)C=C2)/C1=CC3=C(C)C=C(C)N3
Chemical Name
Formula C15H13ClN2O M. Wt 272.73
Purity 98% Storage Store at 4-8°C
Description SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.
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