CYT387 sulfate salt
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1056636-06-6 | Cat. No. | BCP12875 |
| Name | CYT387 sulfate salt | ||
| Synonyms | CYT-387 sulfate;CYT 387 sulfate;momelotinib sulfate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H22N6O2.2(H2SO4) | M. Wt | 610.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: CYT387 inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3 with IC50 of 1400 nM. Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, CHRF-288-11 cells and Ba/F3-TEL-JAK2 cells with IC50 of 200 nM, 1 nM and 700 nM, respectively. In addition, CYT387 has been shown to inhibit erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency with IC50 of 2μ-4 μM [1]. A recent study shows that CYT387 inhibits PI3K/AKT and Ras/MAPK signaling induced by IL-6 and IGF-1. Moreover, CYT387 induces apoptosis as a single agent and synergizes with the conventional anti-MM therapies bortezomib and melphalan in primary multiple myeloma (MM) cells . in vivo: In a murine MPN model, CYT387 normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines. | ||
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