XL888
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1149705-71-4 | Cat. No. | BCP09245 |
| Name | XL888 | ||
| Synonyms | XL-888; XL 888; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C29H37N5O3 | M. Wt | 503.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met. | ||
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