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AZD-1208 Chemical Structure

AZD-1208

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08968CAS No. ：1204144-28-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1204144-28-4 Cat. No. BCP08968
Name AZD-1208
Synonyms AZD1208; AZD 1208;
SMILES
Chemical Name
Formula C21H21N3O2S M. Wt 379.48
Purity 98% Storage Store at 4-8°C
Description AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.
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