PIM447 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1820565-69-2 | Cat. No. | BCP31128 |
| Name | PIM447 dihydrochloride | ||
| Synonyms | LGH447 dihydrochloride;LGH447 2HCl; LGH-447 2HCl; LGH 447 2HCl; PIM-447 2HCl; PIM 447 2HCl; PIM447 2HCl; | ||
| SMILES | CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F.Cl.Cl | ||
| Chemical Name | |||
| Formula | C24H25Cl2F3N4O | M. Wt | 513.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PIM447 Hydrochloride is Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects. LGH447 Hydrochloride is also know as PIM447, PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). | ||
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