Oclacitinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1208319-26-9 | Cat. No. | BCP07898 |
| Name | Oclacitinib | ||
| Synonyms | PF 03394197;PF03394197;PF-03394197; Apoquel; | ||
| SMILES | O=S(C[C@H]1CC[C@H](N(C)C2=C3C(NC=C3)=NC=N2)CC1)(NC)=O | ||
| Chemical Name | |||
| Formula | C15H23N5O2S | M. Wt | 337.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nM. | ||
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