GSK 2334470
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1227911-45-6 | Cat. No. | BCP08386 |
| Name | GSK 2334470 | ||
| Synonyms | GSK2334470; GSK-2334470; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H34N8O | M. Wt | 462.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in HEK293, U87 and mouse embryonic fibroblast cell lines; exhibits limited inhibitory effect on Akt activation. | ||
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