BX795
Data Sheet
For research use only. Not for human use.
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| CAS No. | 702675-74-9 | Cat. No. | BCP01899 |
| Name | BX795 | ||
| Synonyms | BX 795;BX-795; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H26IN7O2S | M. Wt | 591.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. In addition, BX-795, as an inhibitor of the TBK1/IKK?, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. | ||
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