BIX-02565

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13222CAS No. ：1311367-27-7Purity：98%

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CAS No.	1311367-27-7	Cat. No.	BCP13222
Name	BIX-02565
Synonyms	BIX 02565;BIX02565;
SMILES
Chemical Name
Formula	C26H30N6O2	M. Wt	458.56
Purity	98%	Storage	Store at 4-8°C
Description	BIX 02565 is an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure. Besides, BIX 02565 is a multikinase inhibitor, including LRRK2, RET, CLK2, FLT3 and PDGFR. At this point, we returned to the panel of 20 kinases used for optimization to obtain a more accurate picture of kinase selectivity for 24. Six kinases furnished an IC50 less than 1 lM: the live that had shown greater than 80% inhibition in the selectivity count, and PDGFRa which had shown 71% inhibition. Additionally, compound 24 was more than 100-fold selective relative to RSK for the kinase panel, with the exception of LRRK2 and PRKD1, for which compound 24 showed 16- and 35-fold selectivity, respectively. We then expanded the kinase panel to include over 200 additional unique kinases. We were pleased to and that 24 had an IC50 of less than 1 lM for only four other family members (PRKD2, PRKD3, RET, and FLT3). These results con?rmed the power of the selectiv