Darifenacin HBr
Data Sheet
For research use only. Not for human use.
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| CAS No. | 133099-07-7 | Cat. No. | BCP05215 |
| Name | Darifenacin HBr | ||
| Synonyms | Darifenacin hydrobromide; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H30N2O2.HBr | M. Wt | 507.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced concentration-dependent contraction of the isolated bladder of rat. Darifenacin produces a concentration dependent increase in R123 (P-gp probe) accumulation in MDCK cells. Darifenacin stimulates ATPase activity in P-gp membrane in a clear concentration dependent response manner with an estimated ED50 value of 1.6?μM. Darifenacin (100 nM) shows a significantly greater permeability for darifenacin in the basolateral to apical direction resulting in an efflux ratio in BBMEC monolayers of approximately 2.6. | ||
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