Irbesartan

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02004CAS No. ：138402-11-6Purity：98%

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CAS No.	138402-11-6	Cat. No.	BCP02004
Name	Irbesartan
Synonyms	SR-47436;SR 47436;SR47436;BMS-186295;BMS 186295;BMS186295;Avapro;
SMILES
Chemical Name
Formula	C25H28N6O	M. Wt	428.53
Purity	98%	Storage	Store at 4-8°C
Description	Irbesartan competes with angiotensin II (AII) for binding at the AT1 receptor subtype and antagonizes AII-induced contraction in rabbit aorta ring with IC50 of 4 nM. Irbesartan has no affinity for AT2 receptors. Irbesartan (10 μM) blocks angiotensin II induced increase in αv, β1, β3, and β5 integrins, osteopontin, and α-actinin mRNA and protein levels in rat cardiac fibroblasts, leading to the decrease of cell attachment to extracellular matrix (ECM) proteins. Irbesartan treatment markedly induces the expression of the adipogenic marker gene adipose protein 2 (aP2) in 3T3-L1 cells in a concentration-dependent manner with EC50 of 3.5 μM and 3.3-fold induction at the concentration of 10 μM. Irbesartan (10 μM) markedly induces transcriptional activity of the peroxisome proliferator–activated receptor-γ (PPARγ) by 3.4-fold independent of its AT1 receptor blocking action.Pretreatment with Irbesartan (~10 μM) decreases angiotensin II-induced apoptosis in rat vascular smooth muscle cells by b