Tiotropium Bromide hydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 139404-48-1 | Cat. No. | BCP02924 |
| Name | Tiotropium Bromide hydrate | ||
| Synonyms | Spiriva; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H22NO4S2.Br.xH2O | M. Wt | 490.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tiotropium bromide is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease. Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against choliergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) . Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but mor | ||
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