GS-4997 HCl salt
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1448428-05-4 | Cat. No. | BCP20629 |
| Name | GS-4997 HCl salt | ||
| Synonyms | GS-4997; GS4997; GS 4997; Selonsertib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H25ClFN7O | M. Wt | 481.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. | ||
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