GNE-3511
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1496581-76-0 | Cat. No. | BCP19925 |
| Name | GNE-3511 | ||
| Synonyms | GNE3511;GNE 3511; | ||
| SMILES | N#CC1=CC=NC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=C1 | ||
| Chemical Name | |||
| Formula | C23H26F2N6O | M. Wt | 440.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GNE-3511 is a potent and selective dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. GNE-3511 displays protection of primary neurons in an in vitro axon degeneration assay as well as activity in the mouse models of glaucoma/optic neuropathy (optic nerve crush) and Parkinson’s disease (MPTP) after oral dosing. | ||
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