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Sapacitabine Chemical Structure

Sapacitabine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28629CAS No. :151823-14-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 151823-14-2 Cat. No. BCP28629
Name Sapacitabine
Synonyms CS682; CS 682; CS-682; CS682; CYC682; CYC-682;
SMILES
Chemical Name
Formula C26H42N4O5 M. Wt 490.64
Purity 98% Storage Store at 4-8°C
Description Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well.
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