Sapacitabine
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CAS No. | 151823-14-2 | Cat. No. | BCP28629 |
Name | Sapacitabine | ||
Synonyms | CS682; CS 682; CS-682; CS682; CYC682; CYC-682; | ||
SMILES | |||
Chemical Name | |||
Formula | C26H42N4O5 | M. Wt | 490.64 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well. |
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