Diclofenac sodium
Data Sheet
For research use only. Not for human use.
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| CAS No. | 15307-79-6 | Cat. No. | BCP02915 |
| Name | Diclofenac sodium | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C14H10Cl2NNaO2 | M. Wt | 318.13 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. Dc injected at 1.5 microg/g and 3.0 microg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. In vivo test using 30 or 50 microg Dc per 20 g mouse (Swiss Albino variety) significantly (P <0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 micro Ci (3H) deoxythymidine uptake . | ||
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